Digitalis glycosides
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Published by W. Zuchschwerdt Verlag in München, New York .
Written in English


  • Cardiac glycosides.,
  • Digitalis (Drug),
  • Congestive heart failure -- Chemotherapy.,
  • Digitalis Glycosides -- pharmacokinetics.,
  • Digitalis Glycosides -- therapeutic use.,
  • Cardiotonic Agents -- therapeutic use.,
  • Cardiovascular System -- drug effects.,
  • Heart Failure, Congestive -- drug therapy.

Book details:

Edition Notes

Includes bibliographical references.

StatementW. Kirch (ed.).
SeriesKlinische Pharmakologie -- 20, Clinical pharmacology -- 20.
ContributionsKirch, Wilhelm.
The Physical Object
Paginationv, 44 p. :
Number of Pages44
ID Numbers
Open LibraryOL20772115M
ISBN 103886037711

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Research on glycoside kinetics has progressed at a rapid pace, requiring continuing reevaluation of the state of our understanding of this problem. The present article focuses on the effect of disease states (renal, gastrointestinal, thyroid, and cardiac) on the absorption, distribution, and clearance of a number of digitalis glycosides. Digitalis glycosides are a major cause of poisoning in children {01}. The tolerance of newborn infants to digitalis glycosides is variable, {01} since their renal clearance of the medication is reduced. Premature and immature infants are especially sensitive {01}.   The technique of DCCC has seen rapid expansion over the past few years. It was used to isolate three new glycosides from digitalis lanata using the solvent systems CHCl 3-MeOH-H 2 O () and CH 2 Cl 2-MeOH-H 2 O (). Four strophanthidin glycosides, out of a total of eight isolated compounds, were separated from one another by DCCC.   1 Glycosides: Enzymatic and hydrolysis reactions of glycosides, mechanism of action, SAR, therapeutic uses and toxicity of glycosides. Cardiac glycosides of digitalis.

Correction of arrhythmias resulting from digitalis toxicitymaybe attemptedwith lidocaine, procainamide, quinidine, propranolol, or phenytoin. (Digibind), which binds to the digitalis glycoside molecule in the bloodandisexcretedbythekidneys. PotentialNursingDiagnoses Decreasedcardiacoutput(Indications). Later, in , the indication and the toxicity of digitalis were reported in his book, "An account of the Foxglove and some of its medical uses with practical remarks on dropsy, and other diseases". In Denmark, the leaves of Digitalis purpurea or Digitalis lanata were tested for cardiac glycoside activity. Digitalis Glycoside. Digitalis glycosides can be defined as allosteric inhibitors of Na+-, K+-ATPase, a protein cation pump, which uses the energy derived from the hydrolysis of ATP for active transport of potassium ions inside, and sodium ions outside cells (where K+:Na+ is as ). The pharmacokinetics of digitalis glycosides have been the subject of extensive re­ view (IISALO, ; ARONSON, ; PERRIER et ai., ). Research on glycoside kinetics has progressed at a rapid pace, requiring continuing reevaluation Price: $

  There are also other commercial uses of Digitalis lanata other than heart diseases. For example, in South America, the powdered leaves of Digitalis lanata are used to relieve asthma, as sedatives and diuretics. In India, it is also used as an ointment that includes digitalis glycosides and is used to treat wounds and burns. Contraindications. Abstract. Cardiac glycosides have played a prominent role in the therapy of congestive heart failure since William Withering codified its use in his classic monograph on the efficacy of the leaves of the common foxglove plant (Digitalis purpurea) in However, a controversy has arisen in the past two decades about whether the risks of digitalis preparations outweigh their . Digitalis Glycosides Accession Number DBCAT Description. Glycosides from plants of the genus DIGITALIS. Some of these are useful as cardiotonic and anti-arrhythmia agents. Included also are semi-synthetic derivatives of the naturally occurring glycosides. The term has sometimes been used more broadly to include all CARDIAC GLYCOSIDES, but. Be alert for signs of digitalis toxicity. In adults and older children, the first signs of toxicity usually include abdominal pain, anorexia, nausea, vomiting, visual disturbances, bradycardia, and other arrhythmias. In infants and small children, the first symptoms .